Modelling radiation bystander effects and its implications in clinical radiotherapy
Plots showing the spatio-temporal evolution of host-tumour dynamics with and without radiation treatment

Radiation-induced bystander effects are defined as those biological effects expressed, after the irradiation, by cells that are not directly exposed to the radiation. As a consequence of these bystander signals, the affected cells may die or show chromosomal instability as well as further abnormalities. Consequently, the bystander effect has several important implications for radiation protection, radiotherapy and diagnostic radiology. Currently, I am developing a hybrid model incorporating the multiple effects of radiation and radiation induced bystander effects.

Relevant Publications:
  • G.G. Powathil, D.J.A. Adamson, M.A.J. Chaplain, Towards predicting the response of a solid tumour to chemotherapy and radiotherapy treatments: Clinical insights from a computational model , PLOS Computational Biology 2013, 9(7):e1003120, doi:10.1371/journal.pcbi.1003120
  • G.G. Powathil, M.A.J. Chaplain, M. Swat, Systems Oncology: Towards patient-specific treatment regimes informed by multiscale mathematical modelling , Seminars in Cancer Biology 2014, doi:10.1016/j.semcancer.2014.02.003
  • G.G. Powathil, A.J. Munro, M.A.J. Chaplain, M. Swat, Bystander effects and their implications for clinical radiation therapy: Insights from multiscale in silico experiments. Journal of Theoretical Biology 2016 401, 1-14, doi:10.1016/j.jtbi.2016.04.010