Modelling the effects of tumour heterogeneities on tumour growth and treatment responses
Binary images of one of the eight glioma xenographt cross-sections, illustrating tumour blood vessels, perfused vessels, hypoxic area, and total tumour area, respectively.

It is necessary to understand the tumour heterogeneities in order to study cancer progression and plan effective treatment strategies. A growing tumour can change its microenvironment in its own favour by suppressing anti‐tumour factors and producing excess growth factors. There are also increasing evidences in support of the hypothesis that the tumour microenvironment plays an important role in conferring drug resistance, a major cause of relapse contributing to the incurability of cancer.


Relevant Publications:
  • G. Powathil, M. Kohandel, S. Sivaloganathan, M. Milosevic, Modeling the Spatial Distribution of Chronic Tumor Hypoxia: Implications for Experimental and Clinical Studies, Computational and Mathematical Methods in Medicine 2012, Article ID 410602, doi: 10.1155/2012/410602