Multiscale modelling of cancer and its treatments
Cancer as a Multiscale Disease: Mathematical Modeling Approach. Multiscale mathematical models can help in studying cancer evolution and serve as in silico test base for comparing and optimizing various multi-modality anticancer treatments.
Plots of the spatial distribution of the cells in different stages of the cell cycle. (i) Plots from hybrid multiscale CA model and the colours represent various stages of cell-cycle (ii) Plots from hybrid cellular potts model (using Compucell3D) and the colour legend shows the types of the tumour cells
Relevant Publications:
    • G.G. Powathil, K.E. Gordon, L.A. Hill, M.A.J. Chaplain, Modelling the effects of cell-cycle heterogeneity on tumour response to chemotherapy: Biological insights from a hybrid multi-scale cellular automaton model, Journal of Theoretical Biology 2012,308:1, doi: 10.1016/j.jtbi.2012.05.015
    • G.G. Powathil, A. Thompson, M.A.J. Chaplain, The role of cellular heterogeneity on the therapeutic response of breast cancer: Clinical insights from a hybrid multiscale computational model , Published Abstract, Cancer Research 2012, 72(S24):P5-05-02, doi:10.1158/0008-5472.SABCS12-P5-05-02
    • G.G. Powathil, D.J.A. Adamson, M.A.J. Chaplain, Towards predicting the response of a solid tumour to chemotherapy and radiotherapy treatments: Clinical insights from a computational model , PLOS Computational Biology 2013, 9(7):e1003120, doi:10.1371/journal.pcbi.1003120
    • G.G. Powathil, M.A.J. Chaplain, M. Swat, Systems Oncology: Towards patient-specific treatment regimes informed by multiscale mathematical modelling , Seminars in Cancer Biology 2014, doi:10.1016/j.semcancer.2014.02.003
    • G.G. Powathil, M.A.J. Chaplain, Hybrid multiscale approach in cancer modelling and treatment prediction, Contributed book chapter, Mathematical Oncology 2014, A. D’onofrio and A. Gandolfi (editors), Birkhauser, doi: 10.1007/978-1-4939-0458-7_8
    • M.A.J. Chaplain, G.G. Powathil, Multiscale modelling of cancer progression and treatment control: The role of intracellular heterogeneities in chemotherapy treatment , Biophysical Reviews and Letters 2015, doi:10.1142/S1793048015500058