Multiscale modelling of cancer and its treatments
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Cancer as a Multiscale Disease: Mathematical Modeling Approach. Multiscale mathematical models can help in studying cancer evolution and serve as in silico test base for comparing and optimizing various multi-modality anticancer treatments.
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Plots of the spatial distribution of the cells in different stages of the cell cycle. (i) Plots from hybrid multiscale CA model and the colours represent various stages of cell-cycle (ii) Plots from hybrid cellular potts model (using Compucell3D) and the colour legend shows the types of the tumour cells
Relevant Publications:
    • G.G. Powathil, K.E. Gordon, L.A. Hill, M.A.J. Chaplain, Modelling the effects of cell-cycle heterogeneity on tumour response to chemotherapy: Biological insights from a hybrid multi-scale cellular automaton model, Journal of Theoretical Biology 2012,308:1, doi: 10.1016/j.jtbi.2012.05.015
    • G.G. Powathil, A. Thompson, M.A.J. Chaplain, The role of cellular heterogeneity on the therapeutic response of breast cancer: Clinical insights from a hybrid multiscale computational model , Published Abstract, Cancer Research 2012, 72(S24):P5-05-02, doi:10.1158/0008-5472.SABCS12-P5-05-02
    • G.G. Powathil, D.J.A. Adamson, M.A.J. Chaplain, Towards predicting the response of a solid tumour to chemotherapy and radiotherapy treatments: Clinical insights from a computational model , PLOS Computational Biology 2013, 9(7):e1003120, doi:10.1371/journal.pcbi.1003120
    • G.G. Powathil, M.A.J. Chaplain, M. Swat, Systems Oncology: Towards patient-specific treatment regimes informed by multiscale mathematical modelling , Seminars in Cancer Biology 2014, doi:10.1016/j.semcancer.2014.02.003
    • G.G. Powathil, M.A.J. Chaplain, Hybrid multiscale approach in cancer modelling and treatment prediction, Contributed book chapter, Mathematical Oncology 2014, A. D’onofrio and A. Gandolfi (editors), Birkhauser, doi: 10.1007/978-1-4939-0458-7_8
    • M.A.J. Chaplain, G.G. Powathil, Multiscale modelling of cancer progression and treatment control: The role of intracellular heterogeneities in chemotherapy treatment , Biophysical Reviews and Letters 2015, doi:10.1142/S1793048015500058
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